If patients living with T2DM do not take an active role in effectively controlling and treating their diseases, they are prone to a variety of diabetes-related complications that are responsible for the impaired quality of life, disability, and premature death. In China, T2DM has imposed a heavy economic burden on patients and society, and the total economic burden of T2DM and its complications reached 247.8 billion RMB in 2007. According to the International Diabetes Federation (IDF) report, the age-standardized prevalence rate of diabetes in 2019 is 8.3%, which is expected to reach 9.6% in 2045. In recent years, owing to the environmental factors such as sedentary lifestyles and changing dietary habits, type 2 diabetes mellitus (T2DM) has gradually become a global health problem. ConclusionsĪn elevated UCR was significantly associated with an increased risk for CAD in patients living with T2DM. And cubic spline function graph suggested that the influence of UCR level on HR for CAD increased significantly at UCR levels above 6.67. There was a nonlinear trend toward increasing risk of CAD across the groups of UCR. The Kaplan–Meier survival curves indicated that the high group of UCR tended to have a lower event-free survival than the low group and medium group.

In multivariate-adjusted Cox regression models, elevated blood urea nitrogen to creatinine ratio (UCR) was associated with higher risk of CAD in patients living with T2DM. Resultsĭuring a median follow-up of 2.66 years, 1173 CAD were recorded with an event rate of 28.49 events per 1000 person-years. The restricted cubic spline model was used to show the adjusted association between blood UCR and risk of CAD in patients living with T2DM. The Kaplan–Meier survival function plotting and the log-rank test were used to evaluate the event-free survival according to the groups of UCR. Multivariate-adjusted Cox proportional hazard regression models were applied to estimate the association of the blood UCR with the risk of CAD in patients living with T2DM. In order to understand the correlation between variables, we performed correlation analysis on variables that have significant differences between CAD group and non-CAD group. The ANOVA test (continuous indicators) and χ 2 test (categorical indicators) were used to assess the differences of baseline characteristics across the groups of UCR. Primary endpoints were the events of CAD. We analyzed the data from the cohort of 12,299 patients living with type 2 diabetes mellitus.

This study aimed to examine the relationship between blood UCR and the risk of CAD in patients living with new-onset type 2 diabetes mellitus (T2DM). However, the relationship between the Blood Urea Nitrogen to Creatinine (BUN/SCr) ratio (UCR) and the risk of CAD in patients living with new-onset diabetes is unclear. High Blood Urea Nitrogen (BUN) and high Serum Creatinine (SCr) levels are risk factors for Coronary Artery Disease (CAD).

Elevated creatinine normal bun